Thermo Fisher Scientific TDG Polyclonal Antibody
TDG 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합. 핵 내 TDG 단백질 검출에 사용. 재조합 인간 TDG(aa 1-160)로부터 유래한 면역원 사용. 액상 형태로 제공되며 -20°C에서 보관.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–160 of human TDG (NP_003202.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913753 |
Product Specific Information
- Positive test controls include: Mouse brain
- Subcellular localization: Nucleus
Immunogen sequence:
MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA QEPVQEAPKG RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD TFKVKRKVDR FNGVSEAELL TKTLPDILTF NLDIVIIGIN PGLMAAYKGH HYPGPGNHFW
Target Information
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family.
Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine.
This enzyme also removes thymine from C/T and T/T mispairings with lower activity, and can remove uracil and 5-bromouracil from mispairings with guanine.
TDG plays a central role in cellular defense against genetic mutation caused by spontaneous deamination of 5-methylcytosine and cytosine.
This gene may have a pseudogene in the p arm of chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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