Thermo Fisher Scientific HP1 alpha Polyclonal Antibody
HP1 alpha 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA에 사용 가능. Human 및 Mouse 시료에 반응하며, 고순도의 Affinity Chromatography 정제 제품. PBS/glycerol buffer에 보관되며 -20°C에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–100 of human HP1 alpha/CBX5 (NP_001120794.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.12 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913750 |
Product Specific Information
- Positive test controls: HeLa, Jurkat, SH-SY5Y, A-549, MCF7, Mouse brain, 293T
- Subcellular localization: Chromosome, Nucleus, Centromere
Immunogen sequence:
MGKKTKRTAD SSSSEDEEEY VVEKVLDRRV VKGQVEYLLK WKGFSEEHNT WEPEKNLDCP ELISEFMKKY KKMKEGENNK PREKSESNKR KSNFSNSADD
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It interacts with methylated histone H3 on lysine-9 through its chromodomain, acting as an adaptor molecule in gene silencing and chromatin structure regulation. HP1 association with heterochromatin is dependent on SUV39H1 HMTase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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