Thermo Fisher Scientific p21WAF1 (Tumor Suppressor Protein) Monoclonal Antibody (DCS-60.2)
인간 p21 종양억제 단백질을 인식하는 단일클론 항체로, WB, IHC, ICC, Flow 등 다양한 응용에 사용 가능. p53 경로 연구 및 세포주기 조절 분석에 적합. 마우스 및 랫트 반응 없음. 고순도 Protein A/G 정제, 액상 형태로 제공.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p21WAF1 (Tumor Suppressor Protein) Monoclonal Antibody (DCS-60.2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS-60.2 |
| Immunogen | Recombinant full-length human p21 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a crucial role in cellular response to genotoxic stress and DNA damage repair.
In the nucleus, p21 binds and inhibits Cdk1/Cdk2, blocking cell cycle progression from G1 to S phase or G2 to mitosis.
In the cytoplasm, p21 exhibits anti-apoptotic effects by inhibiting caspase 3 and kinases ASK1 and JNK.
p21 has dual roles in carcinogenesis, functioning both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.