Thermo Fisher Scientific p21WAF1 (Tumor Suppressor Protein) Monoclonal Antibody (DCS-60.2)
인간 p21 종양억제 단백질을 인식하는 단일클론 항체로, WB, IHC, ICC, Flow 등 다양한 응용에 사용 가능. p53 경로 연구 및 세포주기 조절 분석에 적합. 마우스 및 랫트 반응 없음. 고순도 Protein A/G 정제, 액상 형태로 제공.
- 카탈로그번호
- 1026-MSM2-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS-60.2 |
| Immunogen | Recombinant full-length human p21 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a crucial role in cellular response to genotoxic stress and DNA damage repair.
In the nucleus, p21 binds and inhibits Cdk1/Cdk2, blocking cell cycle progression from G1 to S phase or G2 to mitosis.
In the cytoplasm, p21 exhibits anti-apoptotic effects by inhibiting caspase 3 and kinases ASK1 and JNK.
p21 has dual roles in carcinogenesis, functioning both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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