Thermo Fisher Scientific Phospho-CD31 (Tyr690) Polyclonal Antibody
CD31(PECAM-1) Tyr690 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능. 1 mg/mL 농도의 액상 제품으로, PBS/glycerol buffer에 보존. 인간, 마우스, 랫트 반응성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PECAM1 (Accession P16284), corresponding to amino acid residues around phosphorylated Tyr690 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817158 |
Product Specific Information
Antibody detects endogenous levels of CD31 only when phosphorylated at Tyr690.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual ITIM motifs. Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases. CD31 is expressed throughout the vascular compartment, mainly at cell junctions. Its N-terminal Ig-like domain mediates homophilic binding, facilitating cell-cell interactions. CD31 plays roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immunoreceptor signaling regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a key regulatory molecule in the vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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