Thermo Fisher Scientific Phospho-NFkB p105 (Ser903) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of NF kappaB p105/p50 only when phosphorylated at Ser903.

Target Information

NF-kB is a nuclear transcription factor activated by various extra- and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. It is synthesized as a p105 precursor protein containing an N-terminal conserved RHD region with nuclear localization signal, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65, forming the functional NF-kB factor. It directs the nuclear translocation of NF-kB and is crucial for DNA binding.
NF-kB has been implicated in pathological processes such as AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.