Thermo Fisher Scientific Phospho-PLCG2 (Tyr759) Polyclonal Antibody
PLCG2 단백질의 Tyr759 인산화 형태를 특이적으로 인식하는 토끼 폴리클로날 항체. Western blot과 면역세포염색에 적합. 인산화 신호전달 연구에 활용 가능. -20°C 보관, PBS/glycerol buffer로 안정화.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PLCG2 (Accession P16885), corresponding to amino acid residues around phosphorylated Tyr759 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817160 |
Product Specific Information
This antibody detects endogenous levels of PLCG2 only when phosphorylated at Tyr759.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including:
- PLC beta1, beta2, beta3, beta4
- PLC gamma1, gamma2
- PLC delta1, delta2
- PLC epsilon
PLC delta1 functions as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It also acts as an effector for transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling.
Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLC delta has been observed in Alzheimer’s disease brains, suggesting a possible role in AD pathology.
PLC delta2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a potential marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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