Thermo Fisher Scientific MEK5 (MAPKK5) Polyclonal Antibody
MEK5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 분석에 적합하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 시약으로 세포 성장 및 분화 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding the epitope -SIAKT- (non-phosphorylated) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: EGF-stimulated A431
- Cellular location: Cytoplasmic
Target Information
MAP2K5 (MEK5) is a serine/threonine kinase belonging to the MAP kinase family. It specifically interacts with and activates MAPK7/ERK5. MEK5 can be phosphorylated and activated by MAP3K3/MEKK3 and atypical protein kinase C isoforms (aPKCs).
This signaling cascade is involved in growth factor–stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may influence colorectal cancer risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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