Thermo Fisher Scientific HMGB1 Polyclonal Antibody

Thermo Fisher Scientific HMGB1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. It is released by damaged or necrotic cells into the extracellular space, functioning as a proinflammatory cytokine. Mouse HMGB1 consists of 215 amino acids forming three domains: two positively charged DNA-binding domains (HMG box A, aa 9–79; box B, aa 89–162) and a negatively charged 30 aa C-terminal acidic tail. Nuclear localization signals are found at residues 28–44 and 180–185. The B box mediates cytokine activity, while the A box interacts with transcription factors. HMGB1 facilitates monocyte migration, cytokine secretion, and T cell–dendritic cell interactions. It signals via RAGE and possibly TLR2/TLR4. HMGB1 is conserved and ubiquitous, acting as a key mediator of inflammation during sterile and infectious responses. Elevated HMGB1 levels are associated with tissue injury, sepsis, arthritis, and ischemia-reperfusion damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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