Thermo Fisher Scientific Silencer Human Cell Cycle Regulation siRNA Library

Thermo Fisher Scientific Silencer™ Human Cell Cycle Regulation siRNA Library

Proteins that regulate cell division are crucial for controlling cell growth and are therefore potentially important drug targets. The Silencer™ Human Cell Cycle Regulation siRNA Library includes 4,398 Ambion™ Silencer siRNAs targeting 1,466 genes.

These siRNA gene targets include:

• Cyclin-dependent kinases (CDKs) crucial for cell cycle progression
• Regulators such as CIP/KIP family and INK4 family inhibitors
• Retinoblastoma family proteins
• DNA replication factors such as CDC proteins

The library was designed using up-to-date genome databases (NCBI RefSeq, GO Consortium, HGNC) and utilizes Ambion Silencer technology for high target specificity and siRNA potency. It is an ideal solution for focused and cost-effective RNAi screening of cell cycle regulation.

주요 특징

• Comprehensive — Expedite cell cycle RNAi functional screens with predefined Silencer Library
• Reliable — Three individual siRNAs per gene target for increased accuracy
• Effective — Proven design reduces off-target impacts at low concentrations
• Convenient — Arrayed format simplifies data de-convolution and accelerates validation
• Customizable — Options for siRNA scales and pooled formats available

Why use the Silencer™ Human Cell Cycle Regulation siRNA Library?

Silencer siRNAs are optimized through bioinformatics selection for high-quality synthesis and guaranteed silencing efficiency. The library provides validated siRNAs with full sequence information, exon targets, gene symbols, aliases, RefSeq numbers, and Locus IDs. Validation results are also included. Contact us for the complete target list.

Efficient Screening and Reliable Data

Ambion Silencer siRNAs ensure gene knockdown at minimal concentrations, reducing off-target effects and false positives. Each siRNA (0.25 nmol) is sufficient for approximately 100 transfections (at 25 nM siRNA, 100 μL volume).

Workflow Flexibility

Thermo Fisher Scientific offers predefined or custom siRNA libraries for human, mouse, or rat genes, available in various scales (1, 2, or 5 nmol). For gene lists or technical consultation, contact your local representative or email RNAilibraries@lifetech.com.

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