Thermo Fisher Scientific AKAP8L/HA95 Polyclonal Antibody
Rabbit polyclonal antibody against human AKAP8L (HA95), suitable for WB, IHC, IHC-P, and IP. Recognizes region 596–646 of AKAP8L. Supplied as liquid, 0.2 mg/mL, stored at 4°C. Recommended for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 596 and 646 of human A kinase (PRKA) anchor protein 8-like (helicase A-binding protein 95 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
AKAP8L (A-kinase anchor protein 8-like, also known as HA95) may play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9 and in CTE-dependent nuclear unspliced mRNA export. It is proposed to target PRKACA to the nucleus and may be involved in nuclear envelope breakdown, chromatin condensation, and anchoring nuclear membranes to chromatin during interphase. AKAP8L is implicated in regulation of DNA replication initiation, cell cycle G2/M transition, histone deacetylation during mitosis, and pre-mRNA splicing.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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