Thermo Fisher Scientific HBEGF Monoclonal Antibody (406316)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Neutralization (Neu)

0.5-2.5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

406316

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2605879

Product Specific Information

In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) Amphiregulin, rhBTC, rhHRG-alpha, rhHRG-beta, rhEGF, rhTGF-alpha, recombinant mouse (rm) Epigen, or rmEpiregulin.

Reconstitute at 0.5 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.