Thermo Fisher Scientific CD44 Monoclonal Antibody (KM81), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.2 µg/1x10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• Request custom conjugation

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and certain epithelial cells of the intestine and breast. Several isoforms exist, including the predominant CD44H isoform found in normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It plays roles in lymphocyte activation, recirculation, and homing. CD44 expression is often upregulated in some carcinomas and may be linked to metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express high levels of CD44, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Transcripts undergo complex alternative splicing, generating many isoforms with diverse functions. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and it may be implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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