Thermo Fisher Scientific CD45RB Monoclonal Antibody (16A), Biotin
마우스 CD45RB를 인식하는 Rat IgG2a 단클론 항체로, Biotin으로 표지된 제품입니다. IHC(F/P) 및 Flow Cytometry에 사용 가능하며, Protein G로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | 0.5 µg/1x10^6 cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A |
| Immunogen | TH2 cell clones, final boost with TH2 clone D10 Fusion Partner: Ag8.653 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539266 |
Additional Formats
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase and a CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. It promotes cell survival by modulating integrin-mediated signal transduction pathways and is involved in DNA fragmentation during apoptosis.
CD45 isoforms differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. Their expression depends on cell type and physiological state. CD45RB is expressed in microglia and inflammatory cells.
In addition to immunoreceptor signaling, CD45 is important in promoting cell survival and is expressed on cells of the human hematopoietic lineage except mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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