Thermo Fisher Scientific CD44 Monoclonal Antibody (KM81), Biotin

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-dependent

Flow Cytometry (Flow)

• 0.2 µg/1x10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• Request custom conjugation

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 acts as a receptor for hyaluronic acid (HA) and plays a role in cell-cell interactions, adhesion, and migration.

It participates in various cellular functions such as lymphocyte activation, recirculation, and homing. CD44 expression may be upregulated in certain carcinomas, potentially linked to metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells show high CD44 levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.

Transcripts for the CD44 gene undergo complex alternative splicing, resulting in multiple functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.