Thermo Fisher Scientific CD44 Monoclonal Antibody (KM81), Biotin
CD44 단백질을 인식하는 Rat IgG2a 형질의 단클론 항체로, Biotin으로 표지되어 있습니다. IHC(F) 및 Flow Cytometry에 사용 가능하며, Bone Marrow Derived Stromal Cells로부터 유래된 면역원으로 제작되었습니다. 단백질 G로 정제되어 안정적인 신뢰성을 제공합니다.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Assay-dependent
Flow Cytometry (Flow)
- 0.2 µg/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KM81 |
| Immunogen | Bone Marrow Derived Stromal Cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539253 |
Additional Formats
Target Information
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 acts as a receptor for hyaluronic acid (HA) and plays a role in cell-cell interactions, adhesion, and migration.
It participates in various cellular functions such as lymphocyte activation, recirculation, and homing. CD44 expression may be upregulated in certain carcinomas, potentially linked to metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells show high CD44 levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Transcripts for the CD44 gene undergo complex alternative splicing, resulting in multiple functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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