Thermo Fisher Scientific CD44 Monoclonal Antibody (IM7.8.1)
Mouse CD44 단백질을 인식하는 Rat IgG2b 모노클로날 항체로, WB, IHC, Flow Cytometry, ELISA, IP 등 다양한 연구용 응용에 적합. 비결합형 포맷으로 제공되며, 고순도 Protein G 정제 및 안정적 PBS 버퍼 보존. CD44 관련 세포 부착 및 이동 연구에 활용 가능.
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Thermo Fisher Scientific CD44 Monoclonal Antibody (IM7.8.1)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.2 µg/1x10^6 cells | 13 publications |
| ELISA (ELISA) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | 5 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IM7.8.1 |
| Immunogen | Mouse CD44 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; -20°C long term (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539259 |
Additional Formats
Product Specific Information
MA5-17875 targets CD44/H-CAM in ELISA, FACS, IHC (F), IHC (P), IP, and WB applications and shows reactivity with Mouse samples.
The immunogen used is mouse CD44.
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and certain epithelial cells. It serves as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. CD44 plays roles in lymphocyte activation, recirculation, and homing, and its expression may be upregulated in certain carcinomas, potentially linked to metastatic potential.
CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Bone marrow myeloid cells and memory T cells exhibit high CD44 expression, while peripheral B and T cells upregulate CD44 upon stimulation.
The CD44 gene undergoes complex alternative splicing, producing diverse isoforms with distinct functions. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be implicated in tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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