Thermo Fisher Scientific DYNLL1 Recombinant Rabbit Monoclonal Antibody (ARC0975)
DYNLL1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA에 적합합니다. HEK293 세포에서 발현되며 높은 특이성과 재현성을 제공합니다. PBS 버퍼에 보관되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0975 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–89 of human DYNLL1 (P63167) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.77 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849391 |
Product Specific Information
Immunogen sequence:
MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain containing a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain component of this complex and also interacts with neuronal nitric oxide synthase (nNOS), inhibiting its activity. Binding of DYNLL1 destabilizes the nNOS dimer, a conformation necessary for activity, thereby regulating various biological processes through modulation of nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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