Thermo Fisher Scientific RAD18 Recombinant Rabbit Monoclonal Antibody (ARC1058)
RAD18 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot 및 ELISA에 적합하며, 인간·마우스·랫트 시료에 반응합니다. HEK293 세포에서 발현되었으며, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA535483
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- pk
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Thermo Fisher Scientific RAD18 Recombinant Rabbit Monoclonal Antibody (ARC1058)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1058 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human Rad18 (Q9NS91) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849384 |
Product Specific Information
Immunogen sequence:
MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI RKFLSYKTQC PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP
Target Information
Human Rad18 (hRad18) is a homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 are essential for post-replication repair, filling gaps in daughter strands during DNA replication of damaged templates. The Rad6–Rad18 complex interacts through a conserved ring-finger motif and binds to damaged DNA via Rad18’s single-stranded DNA binding property. This facilitates lesion bypass and degradation of stalled replication components through Rad6’s ubiquitin-conjugating activity.
Human Rad18 maps to chromosome 3p24–25, a region frequently deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene encodes a 495-amino acid protein (~56 kDa) that is ubiquitously expressed across various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-35483_RAD18_Q9NS91-1_Rabbit.svg, MA5-35483_RAD18_Q9NS91-1_Rabbit_PDP.jpeg)
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