Thermo Fisher Scientific HMGB1 Polyclonal Antibody, DyLight 488

Thermo Fisher Scientific HMGB1 Polyclonal Antibody, DyLight 488

Applications and Tested Dilution

Product Specifications

Target Information

HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. Damaged or necrotic cells release HMGB1 into the extracellular space, where it acts as a proinflammatory cytokine. Mouse HMGB1 is a 215 amino acid single-chain polypeptide with three domains: two positively charged DNA-binding domains (HMG box A, aa 9–79; box B, aa 89–162) and a negatively charged 30-aa C-terminal acidic tail. Nuclear localization signals are found at residues 28–44 and 180–185.
The cytokine activity resides in box B, while box A interacts with transcription factors. HMGB1 mediates inflammation, monocyte migration, cytokine secretion, and T cell-dendritic cell interaction. It signals through receptors such as RAGE, TLR2, and TLR4. HMGB1 is highly conserved, present in nearly all cell types, and plays a key role in sterile and infection-associated inflammatory responses. Elevated HMGB1 levels are observed during tissue injury, sepsis, arthritis, and ischemia-reperfusion conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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