Thermo Fisher Scientific HMGB1 Polyclonal Antibody, DyLight 650

Thermo Fisher Scientific HMGB1 Polyclonal Antibody, DyLight 650

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody will not work in ICC/IF applications.

Target Information

HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. Damaged or necrotic cells release HMGB1 extracellularly, where it acts as a proinflammatory cytokine.
Mouse HMGB1 consists of 215 amino acids with three domains:

• Two positively charged DNA-binding domains (HMG box A: aa 9–79, box B: aa 89–162)
• A negatively charged C-terminal tail (30 aa)

Residues 28–44 and 180–185 contain nuclear localization signals (NLS).
The B box mediates cytokine activity, while the A box interacts with transcription factors.
HMGB1 functions as an inflammatory mediator promoting monocyte migration and cytokine secretion, and facilitates T cell–dendritic cell interaction.
It signals through RAGE and possibly TLR2/TLR4 receptors.
HMGB1 is highly conserved and ubiquitously expressed, serving as a key mediator of inflammation in sterile and infection-associated responses.
Elevated HMGB1 levels are associated with tissue injury, infection, sepsis, arthritis, and ischemia-reperfusion injury.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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