Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody, Biotin
Human, Mouse, Rat에서 반응하는 Biotin 결합 IRE1 alpha 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C 암소 보관. 비인간 영장류 시료에는 반응하지 않음.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide within the human IRE1 alpha protein (within residues 700–800) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153173 |
Product Specific Information
- This antibody does not react with non-human primate samples.
- Suggested positive control: Pancreatic islets and insulinoma cells.
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities and plays a key role in endoplasmic reticulum (ER)-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the ER and initiates the unfolded protein response (UPR) by splicing XBP1 mRNA, converting it into a potent transcriptional activator.
ERN1 is essential for fetal viability and cell survival under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion or dominant-negative inhibition of IRE1 leads to apoptosis under such stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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