Thermo Fisher Scientific Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6), FITC

Thermo Fisher Scientific Phospho-Stat1 (Ser727) Recombinant Rabbit Monoclonal Antibody (Stat1S727-C6), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 5 µL / 1×10⁶ cells
  View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• APC
• PE
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism.
It plays a key role in mediating cell viability in response to stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2.
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of various genes.
STAT1 is activated by multiple ligands including:

• IFN family (IFN-α, IFN-β, IFN-γ, IL-10)
• gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF)
• Receptor tyrosine kinases (EGF, PDGF, CSF-1)
  Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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