Thermo Fisher Scientific PPOX Monoclonal Antibody (2B5)
Thermo Fisher Scientific의 PPOX Monoclonal Antibody (2B5)는 인간 PPOX 단백질을 인식하는 Mouse IgG2a 형 단일클론 항체입니다. Western blot과 ELISA에서 1:500~1:1,000 희석으로 사용 가능하며, 액상 형태로 제공됩니다. 연구용으로만 사용되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B5 |
| Immunogen | PPOX (AAH02357, aa 378–477) partial recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EASGCVLSQE LFQQRAQEAA ATQLGLKEMP SHCLVHLHKN CIPQYTLGHW QKLESARQFL TAHRLPLTLA GASYEGVAVN DCIESGRQAA VSVLGTEPNS
Target Information
Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway and catalyzes the 6-electron oxidation of protoporphyrinogen IX to protoporphyrin IX.
PPOX localizes to the inner mitochondrial membrane in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX leads to variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and/or neurological symptoms.
Rare homozygous variants cause severe PPOX deficiency with early childhood onset of photosensitization, skeletal abnormalities, and sometimes short stature, mental retardation, and convulsions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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