Thermo Fisher Scientific GABRA6 Polyclonal Antibody
GABRA6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 완충액에 보관되며 ProClin 300이 포함되어 있습니다.
- 카탈로그번호
- PA578387
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GABA A Receptor alpha 6 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.98 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2735795 |
Product Specific Information
- Positive Control: Mouse brain, rat brain
- Predicted Reactivity: Human (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A Receptor (GABA-A R) subtype. GABA-A Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABA-A R is a multimeric subunit complex composed of six alpha, four beta, and four gamma subunits, with alternative splicing variants. Expression of alpha and beta subunits results in functional GABA-A Rs sensitive to GABA, while coexpression of a gamma subunit is required for benzodiazepine modulation. Different alpha subunits mediate various benzodiazepine effects, and phosphorylation of beta subunits modulates receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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