Thermo Fisher Scientific GABRA6 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Positive Control: Mouse brain, rat brain
• Predicted Reactivity: Human (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A Receptor (GABA-A R) subtype. GABA-A Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.

The GABA-A R is a multimeric subunit complex composed of six alpha, four beta, and four gamma subunits, with alternative splicing variants. Expression of alpha and beta subunits results in functional GABA-A Rs sensitive to GABA, while coexpression of a gamma subunit is required for benzodiazepine modulation. Different alpha subunits mediate various benzodiazepine effects, and phosphorylation of beta subunits modulates receptor function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.