Thermo Fisher Scientific CLN2 Polyclonal Antibody

Thermo Fisher Scientific CLN2 Polyclonal Antibody

Applications and Tested Dilutions

• Western Blot (WB): 1:500–1:3,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive control: A431
• Predicted reactivity: Mouse (92%), Rat (92%), Dog (92%), Chimpanzee (100%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates and has weaker endopeptidase activity. It is synthesized as a catalytically inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.