Thermo Fisher Scientific Angiotensinogen Polyclonal Antibody
Angiotensinogen 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성 확인. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 혈압 조절 관련 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to amino acids 1–476 (P01019) of Angiotensinogen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153449 |
Product Specific Information
- Recommended positive controls: HepG2, human plasma, mouse plasma, rat plasma
- Predicted reactivity: Chimpanzee (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The AGT gene encodes pre-angiotensinogen (angiotensinogen precursor), expressed primarily in the liver. It is cleaved by renin in response to lowered blood pressure to produce angiotensin I, which is further converted by angiotensin-converting enzyme (ACE) into angiotensin II, a physiologically active peptide involved in blood pressure regulation.
This protein plays a key role in:
- Maintaining blood pressure
- Pathogenesis of essential hypertension and preeclampsia
- Associated with renal tubular dysgenesis, atrial fibrillation, and inflammatory bowel disease
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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