Thermo Fisher Scientific PTH1R Polyclonal Antibody
Rabbit 유래 PTH1R 폴리클로날 항체로, 인간 부갑상선 호르몬 수용체 1을 인식합니다. 파라핀 포매 조직의 면역조직화학(IHC-P)에 적합하며, 열 매개 항원 회복이 권장됩니다. 연구용으로 사용되며, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다.
- 카탈로그번호
- PA532538
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC-P)
- Tested Dilution: 1:50
- Suggested positive control: Parathyroid tissue
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to N-terminus of human parathyroid hormone receptor type 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2550004 |
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer (pH 6.0) for 10 minutes, followed by cooling at room temperature for 20 minutes. Following antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature. A suggested positive control is parathyroid tissue.
Target Information
Parathyroid hormone receptor 1 (PTH1R) is a member of the G-protein coupled receptor family. It acts as a receptor for parathyroid hormone (PTH) and parathyroid hormone-like hormone (PTHLH). The receptor activity is mediated by G proteins, which activate adenylyl cyclase and a phosphatidylinositol-calcium second messenger system.
Defects in this receptor are known to cause Jansen’s metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), and enchondromatosis.
PTH1R expression has been reported in bone, breast, brain, colon, GI tract, kidney, liver, placenta, skin, umbilical cord, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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