Thermo Fisher Scientific THOC5 Polyclonal Antibody
THOC5 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. Human THO complex 5의 25–75번 잔기 영역을 면역원으로 사용하며, 액상 형태로 제공됩니다. 4°C 보관, 1년의 권장 보관 기간을 가집니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human THO complex 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
THOC5 is a component of the THO subcomplex of the TREX complex, which specifically associates with spliced mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism and binds upstream of the exon-junction complex (EJC). It functions in mRNA export via interactions between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5, together with THOC4, participates in NXF1-NXT1 mediated nuclear export of HSP70 mRNA and may be involved in the differentiation of granulocytes and adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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