Thermo Fisher Scientific TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody (J2D10)
인간 TNF-alpha를 특이적으로 인식하는 Mouse IgG1 단클론 항체. ICC/IF, Flow Cytometry, Neutralization 등 다양한 연구 응용에 적합. 단백질 L로 정제된 액상 형태로, 보존제 없이 PBS(pH 7.4)에 용해. -20°C 보관, 동결/해동 반복 피할 것.
- 카탈로그번호
- 7124-MSM4-P1ABX
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Thermo Fisher Scientific TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody (J2D10)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Neutralization (Neu) | Assay-dependent |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J2D10 |
| Immunogen | Recombinant human TNF-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein L |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse.
Target Information
TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cell function, proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
It exists as multimers of two to five noncovalently linked units, showing a single 17 kDa band under non-reducing SDS-PAGE conditions. Knockout studies in mice suggest a neuroprotective role, and TNF alpha has been observed to induce tumor necrosis when injected into tumor-bearing mice.
TNF alpha participates in immune responses against bacterial, viral, parasitic, and fungal infections and contributes to tumor cell cytolysis, synergistic with interferon-gamma. It is implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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