Thermo Fisher Scientific TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody (P/T2)
다종(인간, 마우스 등)에 반응하는 TNF-α 단클론 항체로, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능. IgM, kappa 아이소타입의 비결합 항체로, 1 mg/mL 농도의 액상 형태. 면역조직화학 및 세포 분석 연구용에 적합.
- 카탈로그번호
- 7124-MSM2-P1BX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody (P/T2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Cat, Human, Mouse, Rabbit, Rat, Zebrafish |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P/T2 |
| Immunogen | A hexadecapeptide corresponding to aa115–130 (NGVELRDNQLVVPSEG) of human TNF-α, conjugated to thyroglobulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cell activity, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. It typically exists as multimers (dimers, trimers, pentamers), showing a single 17 kDa band under non-reducing SDS-PAGE.
Knockout studies in mice suggest a neuroprotective function, and TNF alpha induces tumor necrosis in tumor-bearing mice. It plays key roles in immune responses to bacterial, viral, parasitic, and fungal infections, and contributes to tumor cell cytotoxicity, often synergistically with interferon-gamma. TNF alpha is implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.