Thermo Fisher Scientific Phospho-Shp2 (Tyr580) Recombinant Rabbit Monoclonal Antibody (Shp2Y580-4A2)
인간 및 생쥐 시료에 반응하는 인산화 Shp2 (Tyr580) 특이 재조합 토끼 단클론 항체. 높은 특이성과 일관된 로트 간 재현성을 제공하며, Flow Cytometry에 적합. -20°C에서 보관, PBS 기반 완충액 포함.
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Shp2Y580-4A2 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745051 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
The encoded protein belongs to the protein tyrosine phosphatase (PTP) family, which regulates cellular processes such as growth, differentiation, mitosis, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains that bind phospho-tyrosine residues and mediate substrate interactions. It is widely expressed in tissues and plays key roles in signal transduction related to mitogenic activation, metabolism, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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