Thermo Fisher Scientific Phospho-Shp2 (Tyr580) Recombinant Rabbit Monoclonal Antibody (Shp2Y580-4A2), PE
Phospho-Shp2 (Tyr580) PE 결합 재조합 토끼 단일클론 항체로, 인간 및 생쥐 시료에 반응합니다. Flow Cytometry에 적합하며 높은 특이성과 일관성을 제공합니다. PBS 기반 보존 용액으로 4°C에서 안정적으로 보관됩니다.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Shp2Y580-4A2 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745050 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The encoded protein belongs to the protein tyrosine phosphatase (PTP) family, which regulates cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains that mediate phospho-tyrosine binding and substrate interactions. It is widely expressed and plays regulatory roles in signaling pathways related to mitogenic activation, metabolism, transcription, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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