Thermo Fisher Scientific Phospho-MKK7 (Ser271, Thr275) Recombinant Rabbit Monoclonal Antibody (MKK7S271T275-R4F9)
Phospho-MKK7 (Ser271, Thr275) 표적에 특이적인 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. Western blot 및 Flow cytometry에 적합. Lot 간 일관성 우수하며, 동물 유래 성분이 없는 포뮬레이션. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-MKK7 (Ser271, Thr275) Recombinant Rabbit Monoclonal Antibody (MKK7S271T275-R4F9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
Species Reactivity
Human, Mouse, Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MKK7S271T275-R4F9 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser271/Thr275 of human phospho MKK7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745047 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The MKK7 protein is a dual specificity protein kinase belonging to the MAP kinase family. It specifically activates MAPK8/JNK1 and MAPK9/JNK2 and is itself phosphorylated and activated by MAP kinase kinases such as MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.
This kinase mediates signal transduction in response to proinflammatory cytokines and environmental stresses. Multiple alternatively spliced transcript variants exist, but only one has been well-defined.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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