Thermo Fisher Scientific Fibrinogen Polyclonal Antibody
사람, 마우스, 랫트 시료에 반응하는 Sheep Polyclonal 항체로, Human Fibrinogen을 인식합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:400 | - |
| ELISA | 1:5,000–1:50,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human fibrinogen purified from plasma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | Glycine buffered saline, pH 7.4, with <0.1% EACA, <0.01% benzamidine, <1 mM EDTA |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2103806 |
Product Specific Information
Sheep anti-Human fibrinogen antibody recognizes human fibrinogen, a complex approximately 340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of three pairs of alpha, beta, and gamma chains linked by a series of 29 disulfide bonds (Henschen et al., 1983).
Target Information
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, the most abundant component of blood clots.
Fibrinogen consists of a dimer of three pairs of non-identical chains (FGA, FGB, FGG) cross-linked by disulfide bonds in their N-terminal segments. The molecule has two terminal D domains and one central E domain, which are separated when fibrinogen is degraded by plasmin.
Mutations in this gene can lead to disorders such as dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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