Thermo Fisher Scientific Fibrinogen Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

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View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

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Immunocytochemistry (ICC/IF)

1:200-1:400

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ELISA (ELISA)

1:5,000-1:50,000

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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Human fibrinogen purified from plasma. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Fibrinogen,uniProtId:P02671-1,ncbiNodeId:9606,antigenRange:1-866,antigenLength:866,antigenImageFileName:PA1-85429_Fibrinogen_P02671-1_Sheep.svg,antigenImageFileNamePDP:PA1-85429_Fibrinogen_P02671-1_Sheep_PDP.jpeg,sortOrder:1},{targetFamily:Fibrinogen,uniProtId:P02675-1,ncbiNodeId:9606,antigenRange:1-491,antigenLength:491,antigenImageFileName:PA1-85429_Fibrinogen_P02675-1_Sheep.svg,antigenImageFileNamePDP:PA1-85429_Fibrinogen_P02675-1_Sheep_PDP.jpeg,sortOrder:2},{targetFamily:Fibrinogen,uniProtId:P02679-1,ncbiNodeId:9606,antigenRange:1-453,antigenLength:453,antigenImageFileName:PA1-85429_Fibrinogen_P02679-1_Sheep.svg,antigenImageFileNamePDP:PA1-85429_Fibrinogen_P02679-1_Sheep_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5 mg/mL

Purification

Ion-exchange chromatography

Storage buffer

glycine buffered saline, pH 7.4, with <0.1% EACA, <0.01% benzamidine, <1mM EDTA

Contains

<0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2103806

Product Specific Information

Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex approximately 340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of alpha, beta, and gamma chains linked by a series of 29 disulphide bonds (Henschen et al. 1983).

Target Information

Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.