Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
Rabbit Polyclonal Antibody targeting human DNA-PKcs, suitable for Western Blot and Immunoprecipitation. Recognizes region 4075–4128 of DNA-PK catalytic subunit. Unconjugated liquid form, 0.20 mg/mL concentration, stored at 4°C. For research use only.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 4075 and the C-terminus (residue 4128) of human DNA-Dependent Protein Kinase, catalytic subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase, closely related to PI3 kinases, and often inhibited by small molecules designed to target PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been found for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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