Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
DNA-PKcs 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. Human에 반응하며 Mouse에도 예측 반응. 항원 친화 크로마토그래피로 정제, 액상 형태. 연구용으로 DNA 손상 반응 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 4075 and the C-terminus (residue 4128) of human DNA-Dependent Protein Kinase, catalytic subunit (DNA-PKcs) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase related to PI3 kinases and can be inhibited by PI3 kinase-targeting molecules.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex essential for gene expression. The mediator complex interacts with transcriptional activators or nuclear receptors to induce gene expression, possibly by facilitating RNA polymerase II pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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