Thermo Fisher Scientific DDX1 Polyclonal Antibody
DDX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 반응성 및 기타 종에도 예측 반응성을 보입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A300521A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and the C-terminus (residue 697) of human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, and Bovine
Target Information
DDX1 (ATP-dependent RNA helicase DDX1) acts as an ATP-dependent RNA helicase capable of unwinding both RNA-RNA and RNA-DNA duplexes.
It possesses 5′ single-stranded RNA overhang nuclease activity and ATPase activity on various RNA, but not DNA polynucleotides.
DDX1, together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation and positively regulates cyclin CCND2 expression by binding to its promoter region.
It is also a component of a multi-helicase-TICAM1 complex that functions as a cytoplasmic sensor of viral double-stranded RNA, activating antiviral responses and proinflammatory cytokine production via TICAM1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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