Thermo Fisher Scientific CD6 Monoclonal Antibody (MEM-98), PE
인간 CD6 단백질을 타깃하는 단클론 항체로, PE 형광체가 결합되어 유세포분석(Flow Cytometry)에 적합합니다. T 및 B 세포, 백혈병 세포에서 CD6 발현 연구에 활용됩니다. 액상 형태로 제공되며 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-98 |
| Immunogen | Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells, followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125–128). |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, Do Not Freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154519 |
Product Specific Information
This antibody reacts with an extracellular epitope of CD6, a 100–130 kDa single-chain transmembrane glycoprotein expressed on T and B lymphocyte subsets, thymocytes, and acute lymphocytic leukemia cells.
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
It interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6–ALCAM mediated cell adhesion is important for T cell proliferation. CD6 may also modulate CD5 signaling, contributing to fine regulation of immune responses.
Ligation of CD6 has anti-apoptotic effects in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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