Thermo Fisher Scientific CD63 Monoclonal Antibody (MEM-259), PerCP

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular/luminal epitope of CD63 (LAMP-3), a 40–60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages, and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family present in late endosomes, lysosomes, and secretory vesicles. It is also found on the plasma membrane following cell activation and serves as a basophil activation marker. CD63 interacts with integrins, affects phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It functions as a T-cell costimulation molecule and can be used to predict carcinoma prognosis. CD63 is expressed on activated platelets and monocytes/macrophages, weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunctions are associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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