Thermo Fisher Scientific P-Selectin Monoclonal Antibody (AK4)

Applications 및 Tested Dilution

Product Specifications

Additional Formats

• APC
• Biotin
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Functional Application: Blocking.

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, functioning as a calcium-dependent receptor binding sialylated Lewis antigens on neutrophils and monocytes. It plays a key role in inflammation, atherogenesis, thrombosis, and tissue destruction. Clinically, P-selectin helps distinguish heparin-induced thrombocytopenia with and without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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