Thermo Fisher Scientific P-Selectin Monoclonal Antibody (AK4)
Human 및 비인간 영장류 반응성을 가진 P-Selectin (CD62P) 단일클론 항체로 다양한 응용(Flow, WB, ICC 등)에 사용 가능. 액상형, Protein A 정제, 4°C 보관. 세포 접착 및 염증 연구에 적합한 Blocking 기능 항체.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1.5 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK4 |
| Immunogen | Human platelets |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153275 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Functional Application: Blocking.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, functioning as a calcium-dependent receptor binding sialylated Lewis antigens on neutrophils and monocytes. It plays a key role in inflammation, atherogenesis, thrombosis, and tissue destruction. Clinically, P-selectin helps distinguish heparin-induced thrombocytopenia with and without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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