Thermo Fisher Scientific Fibronectin Polyclonal Antibody

Thermo Fisher Scientific Fibronectin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: HepG2, HepG2 (10 mM Nicotinamide and 0.4 mM Trichostatin A treatment for 48 hr), HeLa mock and shFN1, mouse plasma.
• Predicted reactivity: Mouse (92%), Rat (92%), Chicken (88%), Bovine (92%).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers.
It is abundant during embryonic development and tissue remodeling, and also present as a soluble plasma protein. Fibronectin consists of repeating modules forming domains for interaction with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins).
It plays a key role in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin expression is increased in non-small cell lung carcinoma and contributes to tumorigenicity and chemoresistance.
The Fibronectin gene has three regions subject to alternative splicing, potentially producing up to 20 transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.