Thermo Fisher Scientific Fibronectin Polyclonal Antibody
Fibronectin 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, Human, Mouse, Rat 반응성을 가짐. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용으로 사용.
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Thermo Fisher Scientific Fibronectin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | 7 publications |
| Immunohistochemistry (IHC) | - | 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 2 publications |
| Flow Cytometry (Flow) | - | 1 publication |
| ELISA | 1:1,000–1:10,000 | - |
| Immunoprecipitation (IP) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 396–689 of Human Fibronectin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547054 |
Product Specific Information
- Recommended positive controls: HepG2, HepG2 (10 mM Nicotinamide and 0.4 mM Trichostatin A treatment for 48 hr), HeLa mock and shFN1, mouse plasma.
- Predicted reactivity: Mouse (92%), Rat (92%), Chicken (88%), Bovine (92%).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers.
It is abundant during embryonic development and tissue remodeling, and also present as a soluble plasma protein. Fibronectin consists of repeating modules forming domains for interaction with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins).
It plays a key role in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin expression is increased in non-small cell lung carcinoma and contributes to tumorigenicity and chemoresistance.
The Fibronectin gene has three regions subject to alternative splicing, potentially producing up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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