Thermo Fisher Scientific Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Rabbit Monoclonal Antibody (ARC1596)
Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) 인산화 단백질을 검출하는 Recombinant Rabbit Monoclonal Antibody. Western blot 및 ELISA에 적합하며, 높은 특이성과 재현성을 제공. Human, Mouse, Rat 시료에 반응. 연구용으로만 사용 가능.
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- MA535881
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1596 |
| Immunogen | A synthetic phosphorylated peptide around S474 of human PAK4 (O96013) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849779 |
Product Specific Information
Immunogen sequence: RKSLV
Target Information
PAK4 is highly expressed in prostate, testis, and colon. PAK4 interacts tightly with GTP-bound CDC42 and weakly with RAC. It phosphorylates and autophosphorylates, activating the JNK pathway.
PAK5, another PAK family kinase, contains a CDC42/Rac1 interactive binding (CRIB) motif and a Ste20-like kinase domain. It preferentially binds CDC42 in the presence of GTP, and this interaction requires the CRIB motif.
PAK6 translocates into the nucleus with the androgen receptor in response to androgen stimulation and is highly expressed in testis and prostate tissues. It is activated by MAP kinase 6 and p38 MAP kinase, suggesting a role in stress response signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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