Thermo Fisher Scientific Phospho-PKC alpha (Thr638) Recombinant Rabbit Monoclonal Antibody (ARC1591)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence: VLTPP

Target Information

The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are involved in diverse cellular signaling pathways.
They also serve as major receptors for phorbol esters, a class of tumor promoters. Each member has a specific expression profile and distinct cellular role. PKC alpha is implicated in cell adhesion, transformation, cell cycle regulation, and cardiac contractility control based on knockout studies in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.