Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody
Cyclin T1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. Human Cyclin T1의 425-475 잔기 영역을 면역원으로 사용하였으며, 4°C에서 보관합니다. HIV-1 Tat 단백질과 관련된 전사 조절 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of human Cyclin T1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Bovine, Horse, and Chimpanzee.
Target Information
Cyclin T1 encodes a member of the highly conserved cyclin C subfamily. This protein associates with cyclin-dependent kinase 9 (CDK9) to form the positive transcription elongation factor b (p-TEFb) complex. This complex acts as a cofactor for HIV-1 Tat protein and is essential for viral transcription activation. It also regulates transcript elongation by phosphorylating the C-terminal domain of RNA polymerase II. Overexpression of Cyclin T1 is implicated in tumor growth. Multiple transcript variants exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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