Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee

Target Information

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, multiple forms of p-TEFb exist, which may include one of several different cyclins along with cyclin-dependent kinase 9.
The complex containing this cyclin and its kinase partner acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.