Thermo Fisher Scientific Phospho-Formylpeptide Receptor 3 (Thr334, Ser335) Polyclonal Antibody
인산화된 FPR3(Thr334, Ser335)를 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C에서 보관 권장.
- 카탈로그번호
- 7TM0224A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human FPR3 around the phosphorylation site Thr334/Ser335 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The N-formyl peptide receptor (FPR) family comprises three members: FPR, FPR3 (also known as FPRL1, lipoxin A4 receptor, FPRH1, or FPR2), and FPR-like 2 (FPRL2). These are chemotactic G protein-coupled receptors with seven transmembrane domains, expressed on phagocytic leukocytes such as neutrophils and monocytes.
Each receptor has specific residues that determine ligand specificity. FPR3 binds multiple ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide, and beta amyloid (42 amino acids). Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils, playing a role in inflammatory and host defense responses.
FPR3 may mediate inflammation in prion and Alzheimer’s diseases, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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