Thermo Fisher Scientific REST Polyclonal Antibody
REST 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. 고순도 친화 크로마토그래피 정제, PBS/glycerol buffer 저장, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: [참조 없음]
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: [참조 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human REST (Accession Q13127), corresponding to amino acid residues A999–E1049 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852301 |
Product Specific Information
This antibody detects endogenous levels of total REST.
Target Information
REST is a transcriptional repressor that binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. It restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which recruit histone deacetylase to REST-regulated gene promoters. REST mediates repression by recruiting the BHC complex at RE1/NRSE sites, which acts through histone deacetylation and demethylation, functioning as a chromatin modifier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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