Thermo Fisher Scientific ADAP Polyclonal Antibody
Western blot, IHC, ICC/IF에 사용 가능한 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 시료에 반응합니다. FYB1 유래 펩타이드로부터 제작되었으며, PBS 및 글리세롤 완충액에 보관됩니다. 연구용으로 T세포 활성화 관련 단백질 ADAP 검출에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FYB1 (Accession O15117), corresponding to amino acid residues L98–L148 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852298 |
Product Specific Information
Antibody detects endogenous levels of total FYB.
Target Information
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell–antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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