Thermo Fisher Scientific CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), eFluor 450, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.06 µg)/test
• Publications: View 1 publication

Product Specifications

Additional Available Formats

• Unconjugated
• Alexa Fluor 532
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• Brilliant UV 737
• Brilliant Violet 650
• FITC
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 700
• NovaFluor Red 725
• NovaFluor Red 755
• NovaFluor Yellow 610
• NovaFluor Yellow 700
• PE
• PE-Cyanine5.5
• PE-Cyanine7
• Super Bright 436
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The eBio124-1D1 monoclonal antibody reacts with human CD7 (gp40, Leu9), a 40 kDa receptor belonging to the immunoglobulin gene superfamily.
CD7 is expressed on most immature and mature T lymphocytes, T cell leukemias, NK cells, and a small subset of normal and malignant B cells.
Cross-linking CD7 modulates T cell and NK cell activity through calcium flux, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 associates directly with phosphoinositol 3'-kinase, and its ligation induces D-3 phosphoinositide production and tyrosine phosphorylation.

A clonogenic subset of human CD34(+) CD38(-) cord blood cells expressing CD7 has lymphopoietic potential, generating B cells, NK cells, and dendritic cells, but not myeloid or erythroid cells.
CD7(+) phenotype distinguishes primitive lymphoid progenitors from pluripotent stem cells.
In Treg function, CD7 may cooperate with CD28; deficiency in both reduces Treg numbers and suppressive activity.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Pre-titrated; recommended 5 µL (0.06 µg)/test
• Excitation: 405 nm
• Emission: 445 nm
• Laser: Violet Laser
• Filtration: 0.2 µm post-manufacturing filtered
• Fluorophore: eFluor® 450 (alternative to Pacific Blue®)

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
It is expressed on most T lymphocytes and NK cells, and is also used as a marker in leukemia diagnostics.
CD7 ligation modulates T cell and NK cell functions via signaling pathways involving phosphoinositol 3'-kinase and tyrosine phosphorylation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지