Thermo Fisher Scientific ZAP70 Monoclonal Antibody (ZAP70, 2046)
인간 ZAP70 단백질을 인식하는 Mouse IgG2a 단클론 항체로, 면역조직화학(IHC) 및 펩타이드 어레이에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, PBS 버퍼에 보존. T세포 신호전달 연구용으로 적합.
- 카탈로그번호
- 7535-MSM6-P1
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ZAP70 Monoclonal Antibody (ZAP70, 2046)
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
- Peptide Array (Array): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZAP70, 2046 |
| Immunogen | Recombinant fragment (around aa 247–382) of human ZAP70 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B between the SH2 and kinase domains.
Phosphorylation at tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP70 function in lymphocyte signaling, while phosphorylation at tyrosine 292 attenuates activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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