Thermo Fisher Scientific CD154 (CD40 Ligand) Monoclonal Antibody (24-31), APC, eBioscience
인간 및 사이노몰거스 원숭이 CD154 검출용 APC 결합 단클론 항체. Flow Cytometry에 최적화된 24-31 clone. 활성화된 T 세포에서 CD40L 발현 분석에 사용. 고순도 친화 크로마토그래피 정제 및 0.2 µm 필터 처리.
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Thermo Fisher Scientific CD154 (CD40 Ligand) Monoclonal Antibody (24-31), APC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human |
| Published Species | Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 24-31 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1582216 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC-eFluor 780
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Request custom conjugation
Product Specific Information
The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen-presenting cells including B cells, monocytes/macrophages, and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry.
24-31 cross-reacts with the cynomolgus monkey CD154.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometric analysis of activated normal human peripheral blood cells. Recommended use at 5 µL (0.25 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. It stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand induces cytokine production and tumoricidal activity in peripheral blood monocytes and co-stimulates proliferation of activated T cells, accompanied by production of IFN-γ, TNF-α, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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